Amanda has ten years of research experience in tissue engineering, regenerative biomaterials, and stem cell biology. Between her undergraduate and graduate studies, Amanda evaluated the patentability of medical implants as a U.S. Patent Office examiner. Her ability to visualize intellectual property issues through the eyes of an examiner is a valuable asset to her clients. Over the course of her research career, she published several peer-reviewed manuscripts, acquired extramural funding, and delivered podium presentations at several national conferences. During her post-doctoral fellowship within the Emory/Georgia Tech biomedical engineering program, she collaborated with physicians, scientists, and the Emory Office of Technology Transfer to orchestrate the translation of stem cell therapies from the lab to the clinic. During graduate school, she developed synthetic hydrogel surfaces to induce differentiation of cutaneous fibroblasts to cardiomyocytes. Undergraduate research projects included 1) optimization of drug release profiles from an injectable poly(anhydride) bone cement and 2) analysis of intestinal stem cell differentiation after transfection with pancreatic-associated transcription factors.
Vanderbilt University, B.E., Biomedical Engineering, magna cum laude
Washington University, PhD, Biomedical Engineering
Emory University, Post-doctoral training
- U.S. Patent and Trademark Office
Publications & Presentations
Agarwal, U., Smith, A.W., French, K.M., Boopathy, A.V., George, A., Trac, D., Brown, M.E., Shen, M., Jiang, R., Fernandez, J.D., Kogon, B.E., Kanter, K.R., Alsoufi, B., Wagner, M.B., Platt, M.O., Davis, M.E. Age-Dependant Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure. Stem Cells Translational Medicine. 2016; 5(7): 847-979.
Boopathy, A.V., Martinez, M.D., Smith, A.W., Brown, M.E., Garcia, A.J., Davis, M.E. Intramyocardial Delivery of Notch Ligand-Containing Hydrogels Improves Cardiac Function and Angiogenesis Following Infarction. Tissue Eng Part A. 2015. (In press).
McCreedy, D.A., Wilems, T.S., Xu, H., Butts, J.C., Brown, C.R., Smith, A.W., Sakiyama-Elbert, S.E. Survival, differentiation, and migration of high purity mouse embryonic stem cell-derived progenitor motor neurons in fibrin scaffolds after sub-acute spinal cord injury. Biomaterials Science. 2014; 2: 1672-1682.
Smith, A.W., Hoyne, J.D., Nguyen, P.K., McCreedy, D.A., Aly, H. Efimov, I.R., Rentschler, S., Elbert, D.L. Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly (ethylene glycol) (PEG) hydrogels. Biomaterials. 2013; 34: 6559-6571.
Nguyen, P.K., Snyder, C.G., Shields, J.D., Smith, A.W., Elbert, D.L. Clickable Poly- (ethylene glycol) Microsphere Based Cell Scaffolds. Macromolecular Chemistry and Physics. 2013; 8: 948-956.
Smith, A.W., Segar, C.E., Nguyen, P.K., MacEwan, M.R., Efimov, I.R., Elbert, D.L. Long-term culture of HL-1 cardiomyocytes in modular poly(ethylene glycol) microsphere-based scaffolds crosslinked in the phase-separated state. Acta Biomaterialia. 2012; 8: 31-40.
Weiner, A.A., Moore, M.C., Walker, A.H., Shastri, V.P. Modulation of protein release from photocrosslinked networks by gelatin microparticles. Int. J. Pharmaceutics. 2008; 360: 1007-114
Tissue Engineering and Regenerative Medicine (TERMIS) Annual Meeting and Exposition in Atlanta, Georgia. 2013. Smith, A.W. et al. Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels.
Georgia Bio Life Sciences Summit in Atlanta, Georgia. 2013. Smith, A.W. et al. Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels.
Gordon Conference: Signal Transduction in Engineered Extracellular Matrices in Biddeford, Maine. 2012. Smith, A.W., et al. Fine-tuning porous PEG hydrogels for direct reprogramming of mouse fibroblasts to cardiovascular cells.
Tissue Engineering and Regenerative Medicine (TERMIS) Annual Meeting and Exposition in Houston, Texas. 2011. Smith, A.W. et al. Porous poly(ethylene glycol) microsphere-based scaffolds crosslinked around cells while phase separated in dextran solutions exhibit improved elastic properties and enable long term culture of HL-1 cardiomyocytes.
Society for Biomaterials Annual Meeting in Seattle, Washington. 2010. Smith, A.W., et al. Production of Highly Porous Bioactive Hydrogels by Self-Assembly of Phase Separated Poly(ethylene glycol) Microspheres in the Presence of Cells.
Membership & Affiliations
- Georgia Bio
- Women in Bio
- Tissue Engineering and Regenerative Medicine International Society: Commercialization Thematic Working Group
Honors & Awards
- TI:GER Entrepreneurship Fellowship, Georgia Institute of Technology School of Management
- Predoctoral Fellowship, American Heart Association
- National Merit Scholarship, Vanderbilt University